Papers

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited adaptability to dynamic lab conditions, inadequate error handling, and high operational complexity. Here we introduce BioMARS (Biological Multi-Agent Robotic System), an intelligent platform that integrates LLMs, VLMs, and modular robotics to autonomously design, plan, and execute biological experiments. BioMARS uses a hierarchical architecture: the Biologist Agent synthesizes protocols via retrieval-augmented generation; the Technician Agent translates them into executable robotic pseudo-code; and the Inspector Agent ensures procedural integrity through multimodal perception and anomaly detection. The system autonomously conducts cell passaging and culture tasks, matching or exceeding manual performance in viability, consistency, and morphological integrity. It also supports context-aware optimization, outperforming conventional strategies in differentiating retinal pigment epithelial cells. A web interface enables real-time human-AI collaboration, while a modular backend allows scalable integration with laboratory hardware. These results highlight the feasibility of generalizable, AI-driven laboratory automation and the transformative role of language-based reasoning in biological research.

Growing demands for clinical data privacy and storage constraints have spurred advances in Source Free Unsupervised Domain Adaptation (SFUDA). SFUDA addresses the domain shift by adapting models from the source domain to the unseen target domain without accessing source data, even when target-domain labels are unavailable. However, SFUDA faces significant challenges: the absence of source domain data and label supervision in the target domain due to source free and unsupervised settings. To address these issues, we propose HEAL, a novel SFUDA framework that integrates Hierarchical denoising, Edge-guided selection, sizeAware fusion, and Learning-free characteristic. Large-scale cross-modality experiments demonstrate that our method outperforms existing SFUDA approaches,achieving state-of-the-art (SOTA) performance. The source code is publicly available at: https://anonymous.4open.science/r/HEAL-10C5.

Growing demands for clinical data privacy and storage constraints have spurred advances in Source Free Unsupervised Domain Adaptation (SFUDA). SFUDA addresses the domain shift by adapting models from the source domain to the unseen target domain without accessing source data, even when target-domain labels are unavailable. However, SFUDA faces significant challenges: the absence of source domain data and label supervision in the target domain due to source free and unsupervised settings. To address these issues, we propose HEAL, a novel SFUDA framework that integrates Hierarchical denoising, Edge-guided selection, size-Aware fusion, and Learning-free characteristic. Large-scale cross-modality experiments demonstrate that our method outperforms existing SFUDA approaches, achieving state-of-the-art (SOTA) performance. The source code is publicly available at: https://anonymous.4open.science/r/HEAL-10C5.

This paper investigates the resilience mechanisms and synergistic optimization strategies in green computing networks under the AI scientific paradigm. As computing infrastructure increasingly demands both performance and sustainability, traditional optimization approaches face challenges in balancing energy efficiency with network reliability. We propose an AI-driven framework that integrates reinforcement learning and multi-agent systems to dynamically optimize resource allocation while maintaining network resilience. Our approach combines theoretical economic models with practical AI engineering capabilities to analyze real-world computing workloads. Experimental results demonstrate that our method achieves 27% reduction in energy consumption while improving network fault tolerance by 34% compared to baseline approaches. This work contributes to the emerging field of AI for Science by showcasing how automated scientific discovery methods can address complex sustainability challenges in computing infrastructure.

Large language models (LLMs) struggle to effectively utilize a growing number of external tools, such as those defined by the Model Context Protocol (MCP)[ 1], due to prompt bloat and selection complexity. We introduce RAG-MCP, a Retrieval-Augmented Generation framework that overcomes this challenge by offloading tool discovery. RAGMCP uses semantic retrieval to identify the most relevant MCP(s) for a given query from an external index before engaging the LLM. Only the selected tool descriptions are passed to the model, drastically reducing prompt size and simplifying decision-making. Experiments, including an MCP stress test, demonstrate RAG-MCP significantly cuts prompt tokens (e.g., by over 50%) and more than triples tool selection accuracy (43.13% vs 13.62% baseline) on benchmark tasks. RAG-MCP enables scalable and accurate tool integration for LLMs.