This paper introduces a hierarchical framework designed to enhance fault detection in industrial time-series data by effectively distinguishing between benign operational drifts and incipient faults. The core contribution lies in its three-tiered approach: initial change detection using a primary detector (such as an autoencoder or transformer), characterization of these changes through a Multi-Scale Change Signature (MSCS), and classification of changes as either benign or faulty using an unsupervised Drift Characterization Module (DCM) against an Online Normality Baseline (ONB). The framework is designed to be model-agnostic, allowing for the integration of various primary detectors, and incorporates a human-in-the-loop mechanism for adaptive learning and decision-making. The authors demonstrate the framework's effectiveness through experiments on the Tennessee Eastman Process dataset, showing significant improvements in fault detection accuracy and a reduction in false alarms compared to baseline methods. The framework's ability to adapt to benign drifts by incorporating them into the ONB is a key innovation, addressing a common challenge in industrial fault detection where systems often misclassify normal operational variations as faults. The use of MSCS allows for a detailed characterization of changes across multiple temporal scales, enhancing the sensitivity to subtle faults. The ONB system includes safeguards against confirmation bias and fault leakage, ensuring robust adaptation to benign drifts. The human-in-the-loop mechanism, with clear escalation criteria and workload modeling, aims to reduce operator fatigue and improve decision-making. The paper provides a comprehensive evaluation, demonstrating the framework's ability to achieve higher fault detection rates while minimizing false alarms. Overall, this work presents a significant advancement in industrial fault detection by addressing the critical challenge of differentiating between benign drifts and incipient faults, offering a practical and adaptable solution for real-world applications.